Author: Niall Fitzpatrick

A masterclass in selection bias The original study was a pair of multicentre, randomised, double-blind, placebo-controlled phase 3 trials investigating the safety and efficacy of daridorexant in adults with insomnia disorder, published in The Lancet Neurology in 2022. The headline finding was that daridorexant improved both night-time sleep measures and daytime functioning compared with placebo.…